LITAF monoclonal antibody, clone AT1F9
产品名称： LITAF monoclonal antibody, clone AT1F9
英文名称： LITAF monoclonal antibody, clone AT1F9
产品编号： MAB5642
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against full length recombinant LITAF.
- Immunogen:
- Recombinant protein corresponding to full length human LITAF.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG1, kappa
- Storage Buffer:
- In PBS, pH 7.4 (0.1% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Litaf/Simple protein is increased in intestinal tissues from patients with CD and UC, but is unlikely to function as a transcription factor.
Huang Y, Bennett CL.Inflamm Bowel Dis. 2007 Jan;13(1):120-1.
- 2.
- LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines.
Tang X, Marciano DL, Leeman SE, Amar S.Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5132-7. Epub 2005 Mar 25.
- 3.
- Identification and functional characterization of a novel binding site on TNF-alpha promoter.
Tang X, Fenton MJ, Amar S.Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4096-101. Epub 2003 Mar 24.
- Applications
- Western Blot (Cell lysate)
- Cell lysates of HeLa (20 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with LITAF monoclonal antibody, clone AT1F9 (Cat # MAB5642) (1 : 2000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
- Entrez GeneID:
- 9516
- Protein Accession#:
- NP_004853
- Gene Name:
- LITAF
- Gene Alias:
- FLJ38636,MGC116698,MGC116700,MGC116701,MGC125274,MGC125275,MGC125276,PIG7,SIMPLE,TP53I7
- Gene Description:
- lipopolysaccharide-induced TNF factor
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq
- Other Designations:
- LPS-induced TNF-alpha factor,lipopolysaccharide-induced TNF-alpha factor,lipopolysaccharide-induced tumor necrosis factor-alpha factor,p53-induced gene 7 protein,small integral membrane protein of lysosome/late endosome,tumor protein p53 inducible protein